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Updated: Jul 14, 2025
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Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
Published on: October 16, 2017
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PET imaging and quantification of small animals using a clinical SiPM-based camera
Cédric Desmonts1,2, Charline Lasnon3,4, Cyril Jaudet5
1Nuclear Medicine Department, University Hospital of Caen, Avenue de La Côte de Nacre, 14033, Caen Cedex 9, France. desmonts-c@chu-caen.fr.
EJNMMI Physics
|October 7, 2023
Summary
This study demonstrates that a clinical silicon photomultiplier-based PET system can effectively image multiple rats simultaneously for preclinical oncology research. The system provides accurate quantification data for common oncology radionuclides, comparable to dedicated small-animal PET devices.
Area of Science:
- Preclinical oncology research
- Medical imaging technology
- Nuclear medicine
Background:
- Small-animal PET imaging is crucial for preclinical oncology studies.
- This research assesses a clinical SiPM-PET camera for simultaneous rat imaging and quantification.
Purpose of the Study:
- To evaluate a clinical SiPM-PET camera's capability for simultaneous imaging of multiple rats.
- To assess the system's accuracy in quantitative data analysis for preclinical oncology applications.
Main Methods:
- Spatial resolution measured using 18F line sources and NEMA NU 4-2018 phantom.
- Quantification assessed with micro-hollow sphere and 3D-printed rat phantoms for 18F and 68Ga.
- Simultaneous imaging simulated by off-centre phantom placement with scattering sources.
Main Results:
- Radial spatial resolution of 1.78-1.80 mm achieved.
- Recovery coefficients for 18F ranged from 0.40-1.43 (A50) and 0.51-1.43 (Amax).
- High correlation (r²=0.97-0.99) between theoretical and measured activity in simulated tumors.
Conclusions:
- The clinical SiPM-PET system performs comparably to dedicated small-animal PET devices.
- The system is suitable for simultaneous imaging and quantitative analysis of multiple rats in oncology research.
- Effective for radionuclides like 18F and 68Ga commonly used in cancer studies.
