The gut microbiota and coronary artery calcification in Japanese men
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Updated: Jul 14, 2025

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Yukiko Okami1, Hisatomi Arima2, Keiko Kondo3
1NCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Japan..
Background:
The gut microbiota differs between patients with coronary artery disease (CAD) and healthy controls; however, it currently remains unclear whether these differences exist prior to the onset of CAD. We herein investigated the gut microbiota associated with subclinical coronary artery calcification (CAC) in a Japanese population.
Methods:
A total of 663 Japanese men were enrolled in this cross-sectional study. Computed tomography and gut microbiology tests were performed, and CAC scores were calculated using the Agatston method. Participants were categorized into 4 groups based on their CAC scores: CAC = 0, 0
Results:
The mean age of participants was 68.4 years (46-83 years). The numbers of participants in CAC = 0, 0
Conclusions:
The gut microbiota significantly differed from the phylum to genus level in a manner that was dependent on CAC scores, even before the onset of CAD.
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