INFLUENCE OF VASCULAR STENT SURFACE TREATMENT WITH AN ADAPTIVE COMPOSITION FOR IMPROVING ITS BIOCOMPATIBILITY AND...

Area of Science:

• Biomaterials Science
• Vascular Surgery
• Medical Device Engineering

Background:

• Vascular implants can trigger inflammatory responses, leading to complications.
• Surface modification of implants is crucial for enhancing biocompatibility.
• Standard 316L stainless steel stents were used in this study.

Purpose of the Study:

• To evaluate a novel surface treatment for vascular implants to reduce inflammatory reactions.
• To assess the efficacy of adapting composition (AdC) in improving implant biocompatibility.
• To determine the impact of AdC-treated stents on vessel wall morphology.

Main Methods:

• A study involving 34 male Flemish Giant rabbits with induced inflammatory responses in their blood vessels.
• Endovascular implantation of Z-shaped 316L stainless steel stents into the abdominal aorta.
• Comparison between non-treated stents (10 rabbits) and AdC-treated stents (12 rabbits).

Main Results:

• AdC surface treatment of stents led to a significant reduction in vessel wall thickness at the implantation site.
• Vessel wall morphometry confirmed the positive impact of AdC treatment.
• A 100% likelihood of absence of complications was observed with AdC-treated implants in clinical application.

Conclusions:

• Surface treatment of vascular implants with AdC effectively reduces inflammatory reactions and improves biocompatibility.
• AdC treatment offers a promising strategy for enhancing the safety and efficacy of vascular implants.
• The AdC method demonstrates a high potential for clinical application with a favorable safety profile.