Related Experiment Video
Updated: Jul 14, 2025
09:39
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
7.9K
Home-Use Hyaluronic Acid Jet Injectors: Unreliable and Unsafe
Rosalie N S Juch1, Liora Bik2, Neill Boeijink1
1Dermatology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Summary
Home-use needle-free hyaluronic acid (HA) injectors deliver less HA superficially and lack safety features. These devices are unreliable and unsafe for rejuvenation treatments, questioning their general performance.
Area of Science:
- Dermatology
- Cosmetic Science
- Biomedical Engineering
Background:
- Needle-free hyaluronic acid (HA) jet injectors are increasingly popular for cosmetic rejuvenation.
- These devices are accessible online for self-use or by non-professionals in salons.
- Limited data exists on their efficacy and safety.
Purpose of the Study:
- Compare injection efficiency and skin distribution of HA from home-use versus medical jet injectors.
- Evaluate the safety aspects of these devices.
Main Methods:
- HA was injected into ex vivo human skin using 4 home-use and 2 medical jet injectors.
- Intracutaneous HA dose was quantified.
- Cutaneous biodistribution was analyzed using 3D Fluorescent Imaging Cryomicrotome System (3D-FICS).
- Safety was assessed based on manual availability, CE marking, and sterility.
Main Results:
- Home-use injectors delivered significantly lower intracutaneous HA doses compared to medical injectors.
- 3D imaging revealed superficial epidermal distribution with minimal volume for home-use devices.
- Medical injectors achieved larger volumes, primarily in the mid-dermis.
- None of the evaluated home-use injectors met safety standards.
Conclusions:
- Home-use HA injectors studied are unreliable and unsafe for rejuvenation.
- The performance of these treatments is questionable due to device limitations and safety concerns.
