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Major Study Affirming the Relative Safety of Testosterone-replacement Therapy

Bruce Biundo1

  • 1Professional Compounding Centers of America. bbrxman@aol.com.

International Journal of Pharmaceutical Compounding
|October 10, 2023
PubMed

Insights

Testosterone replacement therapy is safe for men with low testosterone and cardiovascular disease. A major study found it poses no greater cardiovascular risk than a placebo.

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Men's Health

Background:

  • Concerns exist regarding cardiovascular risks of testosterone replacement therapy (TRT).
  • Hypogonadal men with symptoms are often undertreated due to safety concerns.
  • Existing research has yielded conflicting results on TRT's cardiovascular safety.

Purpose of the Study:

  • To evaluate the cardiovascular safety of TRT in men with established cardiovascular disease or at high risk.
  • To determine if TRT increases adverse cardiovascular events compared to placebo.

Main Methods:

  • A large-scale research project involving men with cardiovascular disease or high cardiovascular risk.
  • Comparison of TRT group versus placebo group.
  • Monitoring of major adverse cardiovascular events.

Main Results:

  • Testosterone replacement therapy was found to be non-inferior to placebo regarding cardiovascular safety.
  • No significant increase in cardiovascular events was observed in men receiving TRT.
  • The therapy did not worsen outcomes for men with pre-existing cardiovascular conditions.

Conclusions:

  • TRT can be considered a safe option for hypogonadal men with cardiovascular disease or at high risk.
  • The study alleviates concerns about TRT's cardiovascular safety in this patient population.
  • This finding supports improved quality of life for hypogonadal men through safe TRT.

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