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Updated: Jul 13, 2025

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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
Published on: May 16, 2019
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Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues
Kyangwi P Malikidogo1, Manon Isaac1, Adrien Uguen1
1Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans., Rue Charles Sadron, Orléans 45071, France. celia.bonnet@cnrs.fr.
Abstract:
We present the in vitro characterisation of a Gd3+-based contrast agent that responds to Zn2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd3+-accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents.
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