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Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
Published on: June 19, 2018
Strength in diversity: Widening B cell recruitment for broader vaccine protection
Adam K Wheatley1, Stephen J Kent2
1Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Abstract:
Generating potent neutralizing antibodies is a unifying goal of next-generation vaccines. In this issue of Immunity, Ols et al. show that multivalent nanoparticle vaccines displaying RSV F protein can enable recruitment of more diverse B cell specificities into the vaccine response, resulting in increased potency and breadth of antibody immunity to both RSV and the related human metapneumovirus.
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