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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Contact-dependent Signaling01:19

Contact-dependent Signaling

44.7K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
44.7K
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

7.3K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Related Experiment Video

Updated: Jul 13, 2025

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

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Notch-mediated cellular interactions between vascular cells.

Henar Cuervo1, Severin Mühleder1, Irene García-Gónzalez1

  • 1Molecular Genetics of Angiogenesis Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P), Madrid 28029, Spain.

Current Opinion in Cell Biology
|October 13, 2023
PubMed
Summary
This summary is machine-generated.

Notch signaling is crucial for blood vessel development, regulating cell cycles and metabolism to guide arterialization and angiogenesis. It also promotes vascular coverage by signaling in mural cells.

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Related Experiment Videos

Last Updated: Jul 13, 2025

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

7.6K
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
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Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

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Area of Science:

  • Vascular biology
  • Cell signaling
  • Developmental biology

Background:

  • Vessel formation requires coordinated endothelial and mural cell interactions.
  • Notch signaling is a key regulator of vascular development, promoting arterialization and tip-stalk cell phenotypes.
  • Notch influences endothelial cell cycle and metabolism, impacting vessel sprouting and identity.

Purpose of the Study:

  • To review recent findings on Notch signaling in vascular cell differentiation and interactions.
  • To highlight Notch's role in regulating endothelial phenotypes during angiogenesis and arterialization.
  • To discuss Notch's function in pericyte and smooth muscle cell signaling for vascular maturation.

Main Methods:

  • Literature review of recent research on Notch signaling in vascular biology.
  • Analysis of studies investigating Notch's impact on endothelial cell cycle and metabolism.
  • Examination of research on Notch's role in mural cell function and vascular coverage.

Main Results:

  • Notch signaling inhibits endothelial cell cycle and metabolism during arterialization, promoting arterial identity.
  • The same Notch pathway machinery prevents hypermitogenic arrest and excessive sprouting during angiogenesis.
  • Notch signaling in mural cells supports vascular coverage and maturation.

Conclusions:

  • Notch signaling is a central regulator of vascular development, orchestrating endothelial cell behavior and mural cell interactions.
  • Fine-tuning of cell cycle and metabolism by Notch is essential for diverse vascular phenotypes.
  • Understanding Notch signaling provides insights into organ development and maintaining vascular homeostasis.