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Extraction: Advanced Methods00:56

Extraction: Advanced Methods

466
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
466

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Synthesis and Characterization of Functionalized Metal-organic Frameworks
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γ-Cyclodextrin Metal-Organic Frameworks: Do Solvents Make a Difference?

Jia X Oh1, Brent S Murray1, Alan R Mackie1

  • 1Food Colloids and Bioprocessing Group, School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK.

Molecules (Basel, Switzerland)
|October 14, 2023
PubMed
Summary
This summary is machine-generated.

This study compared gamma-cyclodextrin metal-organic frameworks (γ-CD-MOFs) synthesized using methanol versus ethanol. While structural properties were similar, ethanol resulted in lower curcumin encapsulation efficiency and loading capacity due to solubility effects.

Keywords:
characterisationcrystallinitycyclodextrin metal-organic frameworksencapsulationsynthesis

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Area of Science:

  • Materials Science
  • Supramolecular Chemistry
  • Nanotechnology

Background:

  • Methanol is the conventional solvent for synthesizing gamma-cyclodextrin metal-organic frameworks (γ-CD-MOFs).
  • Ethanol offers a potentially safer, food-grade alternative solvent for γ-CD-MOF synthesis.
  • Investigating solvent effects is crucial for optimizing MOF applications.

Purpose of the Study:

  • To compare γ-CD-MOFs synthesized using methanol and ethanol.
  • To evaluate the impact of synthesis solvent on γ-CD-MOF characteristics.
  • To assess the influence of encapsulation solvent on curcumin loading and efficiency.

Main Methods:

  • Synthesis of γ-CD-MOFs using methanol and ethanol.
  • Characterization via SEM, surface area analysis, FTIR, and PXRD.
  • Determination of encapsulation efficiency (EE) and loading capacity (LC) for curcumin.

Main Results:

  • γ-CD-MOFs synthesized with methanol and ethanol showed minimal structural differences.
  • Crystallization from ethanol resulted in larger γ-CD-MOF crystal sizes.
  • Curcumin's higher solubility in ethanol led to significantly lower EE and LC compared to methanol.

Conclusions:

  • Solvent choice impacts γ-CD-MOF crystal morphology and encapsulation performance.
  • Ethanol, while food-grade, reduces curcumin encapsulation effectiveness.
  • Tailoring solvent selection is key to optimizing γ-CD-MOFs for specific compound encapsulation and delivery.