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Lupus Nephritis With Collapsing Glomerulopathy: A Rare Association
Shubham Dubey1, Pranjal Kashiv1, Kapil N Sejpal1
1Department of Nephrology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Lupus nephritis (LN) is a severe lupus complication. Its rare association with collapsing glomerulopathy (CG) may signal severe lupus podocytopathy, requiring urgent treatment for rapid renal failure.
Area of Science:
- Nephrology
- Rheumatology
- Pathology
Background:
- Lupus nephritis (LN) is a critical manifestation of systemic lupus erythematosus (SLE).
- Rapidly progressive renal failure (RPRF) is a rare but severe presentation of crescentic LN.
- Collapsing glomerulopathy (CG) is independently linked to poor kidney survival.
Observation:
- This report details the infrequent co-occurrence of collapsing glomerulopathy (CG) with lupus nephritis (LN).
Findings:
- The combination of LN and CG suggests a potentially more aggressive disease.
- This association may represent a severe subtype of lupus podocytopathy.
Implications:
- Early recognition of LN with CG is crucial for timely and aggressive intervention.
- Understanding this severe presentation can guide treatment strategies and improve patient outcomes in SLE.
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