AUC-RPP: BASIC computer program for compartment model independent pharmacokinetic analysis

Area of Science:

• Pharmacokinetics
• Computational Biology
• Biopharmaceutics

Background:

• Compartment models are widely used for pharmacokinetic analysis.
• Model-independent methods offer an alternative approach, avoiding assumptions about underlying drug distribution.
• Accurate analysis of drug concentration-time data is crucial for understanding pharmacokinetics.

Purpose of the Study:

• To present a computer program for compartment model-independent analysis.
• To facilitate the calculation of key pharmacokinetic parameters like Area Under the Curve (AUC).
• To provide a tool for analyzing data from different drug administration routes.

Main Methods:

• The program utilizes regression analysis of the terminal phase of concentration-time curves.
• It calculates the Area Under the Curve (AUC) and Area Under the First Moment Curve (AUMC).
• The software is designed for intravenous (IV) constant rate infusion, IV push, and extravascular administration.

Main Results:

• The program enables compartment model-independent analysis of pharmacokinetic data.
• It provides accurate calculations of AUC and AUMC through regression analysis.
• For extravascular administration, a simple estimation of the absorption rate constant is performed.

Conclusions:

• The presented BASIC program offers a valuable tool for pharmacokinetic analysis.
• Its model-independent approach simplifies data interpretation for various administration routes.
• The program enhances the ability to estimate key pharmacokinetic parameters efficiently.