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Alloantigen Infusion Activates the Transcriptome of Type 2 Conventional Dendritic Cells

Samantha L Schroth1,2, Rebecca T L Jones1,2, Edward B Thorp1,2,3

  • 1Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Immunohorizons
|October 19, 2023
PubMed
Summary

Innate immune cells, specifically dendritic cell (DC) subsets, respond differently to live versus apoptotic alloantigen infusions. Type 2 conventional DCs (cDC2s) with CCR2 expression uniquely recognize alloantigen, suggesting a role in allorecognition.

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