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Updated: Jul 12, 2025

Assaying the Kinase Activity of LRRK2 in vitro
Published on: January 18, 2012
Targeting LRRK2 mRNA stability in Parkinson's disease
Rachel Fasiczka1, Sabine Hilfiker1
1Department of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Department of Physiology, Pharmacology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Abstract:
In a recent study, Liu and colleagues demonstrated a role for the purine biosynthesis enzyme ATIC and its substrate in regulating the protein levels of the Parkinson's disease kinase LRRK2, which rescues neurodegeneration and neuroinflammation in distinct animal models. This work highlights a novel avenue to target LRRK2 protein levels as a strategy to prevent neurodegeneration in Parkinson's disease.
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