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Decoding Systems Biology of Inflammation Signatures in Cancer Pathogenesis: Pan-Cancer Insights from 12 Common
1Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Türkiye.
Omics : a Journal of Integrative Biology
|October 20, 2023
Summary
This study identified common inflammation-associated gene signatures across 12 cancers, revealing potential biomarkers and drug candidates for personalized oncology treatments.
Area of Science:
- Oncology
- Inflammation Biology
- Genomics
Background:
- Chronic inflammation is a key driver of cancer development.
- The role of inflammatory signaling in the tumor microenvironment is not fully understood across diverse cancer types.
- Identifying inflammation-related molecular signatures is crucial for developing new cancer diagnostics and therapeutics.
Purpose of the Study:
- To uncover gene expression signatures of inflammation-associated proteins linked to tumorigenesis.
- To discover potential system biomarkers and novel drug candidates for oncology.
- To investigate pan-cancer inflammation signatures for broader therapeutic applications.
Main Methods:
- Utilized The Cancer Genome Atlas (TCGA) gene expression data for 12 common cancers.
- Mapped cancer gene profiles to inflammation-related gene sets to identify inflammation-associated differentially expressed genes (i-DEGs).
- Performed pan-cancer analysis to determine common i-DEGs as tumor inflammation signatures (TIS) and conducted drug repurposing analysis.
Main Results:
- A pan-cancer analysis identified a tumor inflammation signature (TIS) comprising 45 proteins, showing prognostic potential and secretion profiles.
- Drug repurposing analysis suggested narcissiclasine, parthenolide, and homoharringtonine as potential therapeutic candidates.
- Identified inflammation-related biomarker candidates, including KNG1, SPP1, and MIF.
Conclusions:
- The identified TIS can serve as a potential system biomarker for prognostic forecasting and distinguishing cancer types.
- Findings support the development of novel prognostic tools and repurposed drugs for multiple cancers.
- Pan-cancer analysis of inflammatory mediators offers new avenues for innovation in cancer diagnostics and therapeutics, advancing precision medicine.
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