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Updated: Jul 12, 2025

Generating Genetically Modified Plasmodium berghei Sporozoites
Published on: May 5, 2023
Still running fast: Plasmodium ookinetes and sporozoites 125 years after their discovery
Mirko Singer1, Friedrich Frischknecht2
1Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, 69120 Heidelberg, Germany.
Abstract:
Plasmodium ookinetes and sporozoites were discovered 125 years ago by MacCallum (J. Exp. Med. 1898;3:117-136) and Ross (Ind. Med. Gaz. 1899;34:1-3), respectively. While the migration capacity of ookinetes was noted immediately, the movements of sporozoites remained enigmatic for decades. Today, we know many proteins involved in parasite migration and start to conceptualize a mechanistic understanding of motility.
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