Related Experiment Video

Updated: Jul 12, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

904

Comparison of Clopidogrel Versus Ticagrelor for Percutaneous Coronary Intervention (PCI) Patients Managed with

Barka Sajid1, Zarnab Tufail2, Maria Asim3

  • 1Sindh Medical College, Karachi, Pakistan.

Therapeutic Hypothermia and Temperature Management
|October 23, 2023
PubMed

Insights

This meta-analysis found no significant differences in bleeding or stent thrombosis between clopidogrel and ticagrelor in patients undergoing percutaneous coronary intervention (PCI) with therapeutic hypothermia (TH). Further randomized studies are needed to confirm these findings.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Therapeutic hypothermia (TH) use after percutaneous coronary intervention (PCI) raises questions about antiplatelet drug efficacy.
  • Clopidogrel and ticagrelor are commonly used post-PCI, but their comparative effectiveness during TH remains debated.

Approach:

  • A systematic review and meta-analysis was conducted, searching PubMed, Cochrane Library, and Scopus up to April 2023.
  • Included five studies with 245 patients comparing clopidogrel and ticagrelor in PCI patients managed with TH.
  • Assessed risk of bias using Newcastle-Ottawa and Cochrane risk of bias tools.

Key Points:

  • No significant differences in bleeding risk were observed between clopidogrel and ticagrelor.
  • Stent thrombosis rates did not differ significantly between the two antiplatelet agents.
  • All-cause mortality showed no significant variation between treatment groups.

Conclusions:

  • Current meta-analytic findings do not support claims of altered clopidogrel efficacy in PCI patients undergoing TH.
  • The study highlights the need for larger, randomized controlled trials to establish definitive conclusions due to the limited sample size.

Keywords:
clopidogrelmeta-analysispercutaneous coronary interventiontherapeutic hypothermiaticagrelor

More Related Videos

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

3.1K
Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

3.0K

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
537
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
11
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
11
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
10
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
12