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Updated: Jul 12, 2025

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Diastereoselective Hydroacylation of Cyclopropenes by Visible-Light Photocatalysis
Sourabh Biswas1, Palasetty Chandu1, Sumit Garai1
1Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India 741246.
Abstract:
An efficient and general strategy for the hydroacylation of cyclopropene is disclosed for synthesizing various 2-acylcyclopropane derivatives under mild reaction conditions. High functional group tolerance of this protocol features a novel route to access a divergent synthesis of acylated cyclopropane in a diastereoselective manner by photoinduced decarboxylation of α-ketoacid followed by acyl radical addition to cyclopropene. Additionally, the regioselective addition of acyl radical at the least substituted olefinic carbon center with trans-selective fashion makes this protocol more appealing toward natural product development.
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