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Related Experiment Video

Updated: Jul 12, 2025

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
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Published on: May 24, 2024

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Elevated FAPI Activity in Ulcerative Fungal Esophagitis.

Yang Xie, Wenxin Tang, Huipan Liu

    Clinical Nuclear Medicine
    |October 26, 2023
    PubMed
    Summary

    Ulcerative fungal esophagitis can mimic esophageal cancer on imaging. Increased uptake of 18F-FDG and 68Ga-FAPI (fibroblast-activating protein inhibitor) may indicate this condition.

    Area of Science:

    • Medical Imaging
    • Mycology
    • Gastroenterology

    Background:

    • Esophageal masses often require differential diagnosis including malignancy and infection.
    • Positron emission tomography (PET) tracers like 18F-FDG are used to assess metabolic activity.
    • Novel tracers like 68Ga-FAPI target fibroblast activation, common in cancer and inflammation.

    Observation:

    • A case presented with an ulcerative fungal esophagitis.
    • The condition showed elevated uptake of 18F-FDG on PET imaging.
    • Significantly, there was also increased uptake of 68Ga-FAPI in the affected esophagus.

    Findings:

    • Ulcerative fungal esophagitis demonstrated increased radiotracer accumulation.
    • The pattern of uptake, particularly with 68Ga-FAPI, resembled that of esophageal cancer.

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  • This highlights the potential for misdiagnosis based solely on imaging findings.

    • Implications:

    • Consider fungal esophagitis in the differential diagnosis of esophageal masses with increased 68Ga-FAPI uptake.
    • This finding may refine the interpretation of PET/CT scans in esophageal diseases.
    • Further research is needed to delineate imaging characteristics of fungal esophagitis versus malignancy.