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Relationship between Composite Dietary Antioxidant Index and Aging
Haiting Wang1,2,3, Yongbing Chen1,2,3
1Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing 100038, China.
Healthcare (Basel, Switzerland)
|October 28, 2023
Summary
A high Composite Dietary Antioxidant Index (CDAI) is linked to a lower risk of aging. This association is stronger in middle-aged, non-smoking individuals, suggesting antioxidant-rich diets may mitigate aging processes.
Area of Science:
- Nutrition Science
- Gerontology
- Public Health
Background:
- Dietary antioxidants are linked to health outcomes but their role in aging is unclear.
- The Composite Dietary Antioxidant Index (CDAI) quantifies overall dietary antioxidant intake.
- Understanding the CDAI-aging relationship can inform public health strategies.
Purpose of the Study:
- To investigate the association between the Composite Dietary Antioxidant Index (CDAI) and aging.
- To explore potential dose-response relationships and modifying factors.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2001-2010.
- Calculated aging as the difference between phenotypic and chronological age.
- Employed weighted logistic regression and restricted cubic splines (RCSs) for analysis.
Main Results:
- A significant inverse correlation was found between CDAI and aging risk (OR = 0.90).
- RCS analysis revealed an L-shaped dose-response relationship.
- The association was more pronounced in middle-aged individuals and non-smokers; high CDAI offset smoking's aging acceleration.
Conclusions:
- High CDAI is associated with a reduced risk of aging, particularly in younger and middle-aged individuals and non-smokers.
- Dietary intake of CDAI components may be a strategy to lower aging risk.
- Further research into dietary interventions for healthy aging is warranted.
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