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Published on: April 8, 2011
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UV-Cured Bio-Based Acrylated Soybean Oil Scaffold Reinforced with Bioactive Glasses
Matteo Bergoglio1, Ziba Najmi2, Andrea Cochis2
1Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy.
Polymers
|October 28, 2023
Summary
This study developed novel 3D-printed scaffolds using soybean oil-based resin and bioactive glass. The resulting composite scaffolds exhibit enhanced mechanical properties and excellent cytocompatibility for tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Developing advanced scaffolds is crucial for tissue engineering.
- Bio-based resins offer sustainable alternatives for biomaterial fabrication.
- Bioactive glasses enhance scaffold integration with bone tissue.
Purpose of the Study:
- To synthesize and characterize 3D-printed composite scaffolds using acrylated epoxidized soybean oil (AESO) and bioactive glass.
- To evaluate the mechanical properties, cytocompatibility, and biocompatibility of these novel scaffolds.
- To investigate the effect of bioactive glass content on scaffold performance.
Main Methods:
- Formulation of a resin system with AESO, isobornyl acrylate (IBOA), and a photo-initiator.
- Incorporation of bioactive glass particles into the resin formulation.
- Fabrication of scaffolds using 3D printing and conventional molding techniques.
- Characterization using techniques like Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), and compression testing.
- Evaluation of cell behavior using human bone marrow mesenchymal stem cells (bMSCs), including metabolic activity, attachment, and viability assays.
Main Results:
- The resin exhibited high reactivity in radical photopolymerization, with minimal impact from bioactive glass.
- 3D-printed scaffolds showed increased glass transition temperature (Tg) and higher modulus compared to molded samples.
- Optimal distribution of bioactive glass within the polymer matrix was observed.
- Scaffolds with higher bioactive glass content demonstrated enhanced cell metabolic activity and attachment, along with good cell viability.
Conclusions:
- 3D printing of AESO-based composite scaffolds reinforced with bioactive glass is a viable approach.
- The fabricated scaffolds possess improved mechanical properties and excellent biocompatibility.
- These novel scaffolds hold significant potential for applications in bone tissue engineering.
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