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End-stage heart failure: The future of heart transplant and artificial heart

Karl Bounader1, Erwan Flécher2

  • 1Department of Cardiac Surgery, La Pitié Sâlpétrière Charles Foix Hospital, Paris, France.

Presse Medicale (Paris, France : 1983)
|October 28, 2023
PubMed

Insights

Heart transplantation is the gold standard for end-stage heart failure but faces graft shortages and immunosuppression risks. Mechanical circulatory support offers an alternative, with newer devices potentially achieving comparable outcomes.

Area of Science:

  • Cardiology
  • Medical Devices
  • Surgical Innovation

Background:

  • Outcomes for heart transplantation (HTx) and left ventricular assist devices (LVADs) have significantly improved.
  • HTx remains the gold standard for end-stage heart failure.
  • Limitations of HTx include graft scarcity and long-term immunosuppression complications.

Conclusions:

  • Despite challenges, heart transplantation remains the preferred therapy.
  • Mechanical circulatory support is indispensable for managing heart failure.
  • Future research and device innovation are key to optimizing outcomes for both therapies.

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