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The development and application of FET-based biosensors.

P Bergveld

    Biosensors
    |January 1, 1986
    PubMed
    Summary

    This study details the pH-sensitive ion-selective field-effect transistor (ISFET) biosensor for intravascular blood pH monitoring. It highlights the device

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    Area of Science:

    • Biomedical Engineering
    • Sensor Technology
    • Analytical Chemistry

    Background:

    • Biosensors are crucial for real-time biological measurements.
    • Existing methods for blood pH monitoring have limitations.
    • Ion-selective field-effect transistors (ISFETs) offer potential for in-vivo sensing.

    Purpose of the Study:

    • To provide a detailed overview of pH-sensitive ISFET biosensors.
    • To discuss the clinical investigation of ISFETs for intravascular blood pH recording.
    • To explore future developments in FET-based biosensors.

    Main Methods:

    • Review of ISFET biosensor principles.
    • Analysis of clinical investigation data for blood pH monitoring.
    • Discussion of performance, advantages, and limitations.

    Main Results:

    • ISFET biosensors show promise for accurate intravascular blood pH measurement.
    • Key advantages include real-time monitoring and potential for miniaturization.
    • Areas for improvement include long-term stability and biocompatibility.

    Conclusions:

    • pH-sensitive ISFETs represent a significant advancement in biosensor technology for critical care.
    • Further development is expected to enhance their clinical utility.
    • FET-based biosensors are poised for broader applications in medical diagnostics.

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