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08:15
A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
Published on: February 2, 2024
849
Using the hazard function to evaluate hepatocellular carcinoma recurrence risk after curative resection.
Wei-Feng Li1, Sin-Hua Moi2,3, Yueh-Wei Liu1
1Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Kaohsiung, Taiwan.
Updates in Surgery
|October 31, 2023
Summary
Predicting hepatocellular carcinoma (HCC) recurrence is key for surveillance. This study found HCC recurrence hazard peaks vary significantly based on risk factors like tumor burden and liver disease stage.
Area of Science:
- Hepatobiliary Surgery
- Oncology
- Medical Statistics
Background:
- Hepatocellular carcinoma (HCC) recurrence after liver resection (LR) necessitates effective surveillance strategies.
- Understanding recurrence timing and hazard is crucial for patient management.
Purpose of the Study:
- To analyze recurrence hazard and peak recurrence time transitions in HCC patients post-LR using hazard function analysis.
- To identify how various risk factors influence HCC recurrence patterns.
Main Methods:
- Analysis of recurrence hazard and patterns in 1204 HCC patients undergoing LR (2007-2018).
- Subgroup analysis based on established HCC recurrence risk factors.
- Utilized hazard function to determine peak recurrence rates and timing.
Main Results:
- Overall HCC recurrence hazard peaked at 7.2 months (peak hazard rate [pHR]: 0.0197).
- High-risk factors (high tumor burden, AFP ≥ 400 ng/ml, pT3-4) showed peaks within the first year.
- Cirrhosis, Barcelona Clinic Liver Cancer stage B, and poor differentiation exhibited varied peak recurrences within 3-5 years.
Conclusions:
- HCC recurrence hazard and patterns are highly variable, significantly influenced by individual risk factors.
- Hazard function analysis provides valuable insights into predicting recurrence timing and intensity.
- Tailored surveillance strategies based on risk stratification may improve outcomes for HCC patients post-LR.
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