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Published on: November 17, 2023
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The causal relationship between hypothyroidism and frozen shoulder: A two-sample Mendelian randomization
1Ya'an Hospital of Traditional Chinese Medicine, Sichuan, China.
Medicine
|October 31, 2023
Summary
Hypothyroidism increases the risk of developing frozen shoulder. This genetic study found a causal link, suggesting that managing hypothyroidism may help prevent frozen shoulder occurrences.
Area of Science:
- Endocrinology and Musculoskeletal Health
- Utilizes genetic epidemiology to explore disease relationships.
Background:
- Frozen shoulder (adhesive capsulitis) is a common condition with multifactorial causes.
- Hypothyroidism is a known endocrine disorder that can affect various bodily systems.
Purpose of the Study:
- To investigate the potential causal relationship between hypothyroidism and frozen shoulder.
- To determine if hypothyroidism is a risk factor for developing frozen shoulder using genetic data.
Main Methods:
- Employed a two-sample Mendelian randomization (MR) approach.
- Utilized large-scale genome-wide association study (GWAS) data from European ancestry populations.
- Applied inverse variance weighting (IVW), weighted median (WME), and MR-Egger methods for causal inference and sensitivity analyses.
Main Results:
- Mendelian randomization analysis indicated that hypothyroidism is a significant risk factor for frozen shoulder (OR: 1.07, 95% CI: 1.01-1.14, P = .024).
- Sensitivity analyses confirmed the robustness of the findings and found no evidence of significant pleiotropy.
- Results suggest a higher prevalence of frozen shoulder in individuals with hypothyroidism.
Conclusions:
- Hypothyroidism is causally linked to an increased risk of frozen shoulder.
- Active management and control of hypothyroidism may be a viable strategy to reduce the incidence of frozen shoulder.
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