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Physical Properties of Ultrafine Bubbles Generated Using a Generator System.

Shingo Miyamoto1, Toyofumi Hirakawa2, Yukiko Noguchi3

  • 1Department of Obstetrics & Gynecology, School of Medicine, Iwate Medical University, Iwate, Japan; smiya@fukuoka-u.ac.jp.

In Vivo (Athens, Greece)
|October 31, 2023
PubMed
Summary
This summary is machine-generated.

Ultrafine bubbles (UFBs) can be generated at high concentrations and remain stable for up to six months. This research confirms UFBs

Keywords:
Ultrafine bubblescavitationhydrodynamicshydrophobic gasultrasonics

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Area of Science:

  • Nanotechnology
  • Biotechnology
  • Physical Chemistry

Background:

  • Ultrafine bubbles (UFBs) exhibit promising physical and biological properties.
  • Challenges exist in determining optimal UFB concentrations and lifespans for biological applications.
  • Understanding UFB stability is crucial for their effective use in research.

Purpose of the Study:

  • To determine the maximum concentration and longest lifespan of UFBs.
  • To assess the validity of UFBs for evaluating cell properties.
  • To investigate UFB behavior in ultrapure water and cell culture media.

Main Methods:

  • UFBs were generated using a specialized system with various gases.
  • Nanoparticle tracking analysis measured UFB size and concentration.
  • UFB stability was monitored over six months in different solutions.

Main Results:

  • UFB concentration increased with generator operation time, reaching a stable state.
  • UFBs maintained approximately 70% of their initial concentration for up to six months.
  • UFB size increased slightly initially and remained stable thereafter.
  • Nitrogen gas UFBs significantly affected cell numbers at various concentrations.

Conclusions:

  • The UFB generator system produces controllable concentrations at suitable temperatures.
  • UFBs demonstrate long-term stability, making them suitable for cell culture applications.
  • This study validates UFBs as a tool for assessing cell properties.