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High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
Published on: January 27, 2013
Intracellular Zn(II) induced turn-on fluorescence of an L-phenylalanine-derived pseudopeptide
Arpna Tamrakar1, Praveen Kumar2, Neha Garg2
1Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi-221005, India. mdpandey.chem@bhu.ac.in.
Abstract:
A C2 symmetric L-phenylalanine-derived pseudopeptide has been synthesized for selective and sensitive recognition of Zn(II) ions in aqueous-organic media. The pseudopeptidic probes exhibit intracellular Zn(II) ion-sensing capabilities as demonstrated via live-cell fluorescence studies on RAW264.7 cells. Hence, we present a bioinspired pseudopeptide for potential biological applications involving intracellular Zn(II) ion detection.

