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Postnatal Corticosteroids To Prevent Bronchopulmonary Dysplasia
Erik A Jensen1, Kristi L Watterberg2
1Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA.
Postnatal corticosteroids may reduce respiratory problems in very preterm infants but carry risks. This review weighs the benefits against potential adverse effects of these anti-inflammatory drugs for preventing bronchopulmonary dysplasia (BPD).
Area of Science:
- Neonatal medicine
- Pediatric respiratory medicine
Background:
- Bronchopulmonary dysplasia (BPD) is a severe chronic lung disease affecting very preterm infants.
- Inflammatory processes in utero and postnatally contribute to BPD development.
- Corticosteroids possess anti-inflammatory properties that may mitigate BPD risk.
Conclusions:
- Postnatal corticosteroids offer a potential therapeutic strategy for BPD prevention.
- Careful consideration of the risk-benefit profile is crucial.
- Further research is needed to optimize use and minimize harm.
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