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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
Published on: November 9, 2020
Mini PROTACs: N-end rule-mediated degradation on the horizon
Yanfen Liu1, Zhangshun Wang1, Yong Cang1
1School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Abstract:
Heterobifunctional proteolysis-targeting chimeras (PROTACs) offer a promising cancer treatment avenue by efficiently degrading unwanted cellular proteins. A recent study from Zhang et al. demonstrated the successful utilization of the N-end rule in PROTAC design, allowing for a modular degradation rate tailored to the oncogenic driver BCR-ABL.
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