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Updated: Jul 11, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Regioselective Coupling of Different Conjugate Esters by Magnesium Metal Reduction: A Route to Unsymmetrical Adipic
Tianyuan Zhang1,2, Jiawu Zhang1, Akihiro Mori1
1Department of Materials Science and Bioengineering, Nagaoka University of Technology 1603-1, Kamitomioka-cho, Nagaoka, Niigata 940-2188, Japan.
Abstract:
A novel tactic to synthesize unsymmetrical 3-aryladipic acid esters has been developed via magnesium-promoted reductive coupling of ethyl cinnamates with methyl acrylate. In the present methodology, 3-aryladipic acid derivatives were prepared with good functional group tolerance and a wide substrate scope under very mild reaction conditions in good yields. The application of this reaction to dienic acid esters led to the successful control of the reaction to give 5-aryl-oct-3-enedioic acid esters with high regioselectivity.
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