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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Longitudinal Research02:20

Longitudinal Research

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Teeth01:15

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Replicative Cell Senescence02:15

Replicative Cell Senescence

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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Related Experiment Video

Updated: Jul 11, 2025

Oral Health Assessment by Lay Personnel for Older Adults
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Geroscience: Aging and Oral Health Research.

J A Weintraub1, M Kaeberlein2, C Perissinotto3

  • 1Department of Pediatric and Public Health, Adams School of Dentistry University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Advances in Dental Research
|November 7, 2023
PubMed
Summary
This summary is machine-generated.

Geroscience research identifies interventions to slow aging and prevent diseases, including oral conditions. Advances in understanding aging

Keywords:
cognitive dysfunctiondelivery of health carelonelinessnutritional statusperiodontal diseasestooth loss

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Area of Science:

  • Gerontology and Dental Research
  • Translational Science
  • Health Span Research

Background:

  • Aging research identifies interventions targeting "hallmarks of aging" to delay disease onset.
  • Oral health is increasingly recognized as integral to overall health and longevity.
  • Geroscience links aging processes to oral health, impacting systemic conditions.

Purpose of the Study:

  • Summarize key findings from the "Geroscience: Aging and Oral Health Research" session.
  • Highlight the translational research spectrum from basic science to health policy.
  • Emphasize the need for improved oral health span and equity in older adults.

Main Methods:

  • Review of presentations from a 3-part session at the 2023 American Association for Dental, Oral, and Craniofacial Research meeting.
  • Discussion of research spanning molecular mechanisms, behavioral science, and healthcare delivery.
  • Synthesis of data on aging, oral health, and systemic disease connections.

Main Results:

  • Common molecular pathways link aging and oral cancer; periodontal microflora may influence Alzheimer's disease.
  • Loneliness, isolation, and cognitive decline impact oral health, eating ability, and systemic health in older adults.
  • Significant barriers exist in accessing dental care for older adults, necessitating innovative delivery models.

Conclusions:

  • Interventions targeting aging hallmarks can improve oral health and prevent disease.
  • Addressing social determinants and integrating medical-dental data is crucial for oral health equity.
  • Future research should focus on improving oral health span, reducing disparities, and enhancing care access through policy and technology.