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Updated: Jun 30, 2026

11:10
Cryopreservation of Preimplantation Embryos of Cattle, Sheep, and Goats
Published on: August 5, 2011
30.8K
Enhancement of cryopreservation with intracellularly permeable zwitterionic polymers
Ryota Yamasaki1, Robin Rajan1, Kazuaki Matsumura1
1School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan. mkazuaki@jaist.ac.jp.
Abstract:
A novel copolymer containing zwitterionic and methylsulfinyl structures was developed, which enhanced cryoprotective efficacy by enabling intracellular cytoplasmic permeation without relying on mediated endocytosis and diffused out of the cells within approximately 30 min, making it more advantageous than polymeric nanoparticles for the transport of membrane-impermeable cryoprotectants such as trehalose.

