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Updated: Jul 11, 2025

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
Published on: December 6, 2024
Physiology and Intravascular Imaging Coregistration-Best of all Worlds?
Tobin Joseph1, Michael Foley1, Rasha Al-Lamee2
1National Heart and Lung Institute, Imperial College London, Du Cane Road, London, W120HS, UK; Imperial College Healthcare NHS Trust, Du Cane Road, London, W120HS, UK.
Abstract:
Percutaneous coronary intervention is increasingly guided by coronary physiology and optimized using intravascular imaging. Pressure-based measurements determine the significance of a stenosis using hyperemic or nonhyperemic pressure ratios (eg, the instantaneous wave-free ratio). Intravascular ultrasound and optical coherence tomography provide cross-sectional and longitudinal detail regarding plaque composition and vessel characteristics. These facilitate lesion preparation and optimization of stent sizing and positioning. This review explores the evidence-base and practical aspects of coregistering pressure gradient assessment and intravascular imaging with angiography. We then discuss gaps in the evidence and what is needed to help integrate these techniques into clinical practice.
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