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Updated: Jul 11, 2025

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IPSOS trial: A "game changer" redefining first-line immunotherapy in platinum-ineligible NSCLC
Miguel García-Pardo1, Laura Mezquita2
1Department of Medical Oncology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Abstract:
First-line therapy for advanced non-small cell lung cancer (NSCLC) involves immunotherapy with or without platinum-based chemotherapy; however, not all patients are fit enough. In the IPSOS trial, atezolizumab monotherapy demonstrated a clinical benefit in platinum-ineligible patients with advanced NSCLC, redefining first-line immunotherapy, and breaking barriers for unfit population in NSCLC.
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