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Related Experiment Video

Updated: Jul 11, 2025

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

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Fascicle-Selective Ultrasound-Powered Bidirectional Wireless Peripheral Nerve Interface IC.

Jianxiong Xu, Jose Sales Filho, Sudip Nag

    IEEE Transactions on Biomedical Circuits and Systems
    |November 13, 2023
    PubMed
    Summary

    This study introduces a novel, wireless, battery-free neural interface for peripheral nervous system (PNS) applications. It enables precise, non-invasive nerve stimulation and recording for adaptive neuromodulation therapies.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Medical Devices

    Background:

    • Current peripheral nervous system (PNS) interfaces often require invasive procedures or lack precision.
    • Adaptive neuromodulation therapies for conditions like paralysis and amputation need advanced neural interfaces.

    Purpose of the Study:

    • To develop and validate a minimally invasive, wireless, and battery-free neural interface for the PNS.
    • To achieve fascicle-selective neural recording and stimulation without nerve penetration.

    Main Methods:

    • Integration of a millimeter-scale, fascicle-selective integrated circuit (IC) with extraneural channels.
    • Utilization of ultrasonic energy harvesting for wireless power and data transmission.
    • Development of a wearable interrogator with machine-learning capabilities for neural pathway classification and temporal interference stimulation.

    Main Results:

    • Demonstrated precise deep fascicle selectivity for neural recording and stimulation.
    • Achieved high performance metrics for the neural analog-to-digital converter (ADC) and ultra-low power RF transmitter.
    • Successful in vivo validation of selective neural fascicle stimulation and recording in rat sciatic nerves.

    Conclusions:

    • The developed PNS neural interface offers a promising, non-invasive solution for adaptive neuromodulation.
    • This technology can provide alternative treatment options for neurological disorders and sensory deficits.
    • The system has the potential to significantly improve the quality of life for patients with neurological conditions.