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Technical Note: Impact of impurities on Yttrium-90 glass microsphere activity quantitation
Bradley J Beattie1, Assen S Kirov1, Adam L Kesner1
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA.
Medical Physics
|November 13, 2023
Summary
Radionuclide impurities in 90 Y microspheres can lead to significant overestimates of activity, impacting dose calibrator and PET measurements. Independent monitoring of these impurities is crucial for accurate dosimetry and clinical use.
Area of Science:
- Radiochemistry
- Nuclear Medicine
- Medical Physics
Background:
- Glass 90 Y microspheres are used in internal implantation but contain radionuclide impurities.
- These impurities are not independently monitored and can be detected by clinical instruments like dose calibrators and PET cameras.
Conclusions:
- Typical impurity levels have acceptable impact on patient absorbed dose but can adversely affect 90 Y radioactivity measurements.
- There is a lack of independent verification and monitoring of impurity levels in the field.
- Accurate activity quantitation for dosimetry requires accounting for radionuclide impurities.
