Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

89.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
89.0K
Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

9.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
9.0K
Nucleic acids02:43

Nucleic acids

163.3K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
163.3K
Nucleic Acids02:43

Nucleic Acids

44.3K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
44.3K
Sanger Sequencing01:57

Sanger Sequencing

754.6K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
754.6K
Nucleic Acid Structure01:25

Nucleic Acid Structure

6.2K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How can biological databases support the new UN mechanism for benefit-sharing from digital sequence information?

Scientific data·2026
Same author

A comprehensive database for biological data derived from sewage in five European cities.

Database : the journal of biological databases and curation·2026
Same author

The European Nucleotide Archive in 2025.

Nucleic acids research·2025
Same author

BioSamples database: the global hub for sample metadata and multi-omics integration.

Nucleic acids research·2025
Same author

Microgeographic genomic variation and connectivity in an endangered semiaquatic mammal.

BMC ecology and evolution·2025
Same author

A Call for Action: Lessons Learned From a Pilot to Share a Complex, Linked COVID-19 Cohort Dataset for Open Science.

JMIR public health and surveillance·2025
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Jul 11, 2025

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
15:28

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Published on: September 3, 2009

20.3K

The European Nucleotide Archive in 2023.

David Yuan1, Alisha Ahamed1, Josephine Burgin1

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Nucleic Acids Research
|November 13, 2023
PubMed
Summary
This summary is machine-generated.

The European Nucleotide Archive (ENA) enhanced its services in 2023, focusing on data FAIRness, pandemic preparedness, and foundational technologies to better serve the global bioinformatics community.

More Related Videos

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.6K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.0K

Related Experiment Videos

Last Updated: Jul 11, 2025

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
15:28

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Published on: September 3, 2009

20.3K
Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.6K
Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.0K

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • The European Nucleotide Archive (ENA) is a key resource for sequence data submission, processing, archiving, and dissemination.
  • It is part of the International Nucleotide Sequence Database Collaboration (INSDC) and serves the global bioinformatics community.
  • ENA supports diverse data types and enriches them with contextual metadata.

Purpose of the Study:

  • To report on recent progress and improvements to ENA services in 2023.
  • To highlight advancements in data FAIRness, pandemic preparedness, and foundational technologies.
  • To detail enhancements supporting genomic surveillance and pathogen data mobilization.

Main Methods:

  • Implemented minimal spatiotemporal annotation requirements for FAIR data.
  • Developed a metadata-based classification system and incorporated third-party metadata curations.
  • Enhanced INSDC data exchange pipelines and invested in site reliability engineering.
  • Adapted services for broader pathogen surveillance, building on SARS-CoV-2 data support.

Main Results:

  • Improved FAIRness of ENA data through enhanced metadata and visualization tools (ENA Notebooks).
  • Strengthened foundational infrastructure with improved data synchronization and reliability.
  • Expanded capabilities for genomic surveillance and pathogen data management.
  • Introduced new visualization platform, ENA Notebooks, for rapid data exploration.

Conclusions:

  • ENA has made significant advancements in 2023, enhancing data accessibility, reliability, and utility.
  • These improvements bolster the ENA's role in supporting global research, particularly in genomics and public health surveillance.
  • The focus on FAIR principles and robust infrastructure ensures continued valuable service to the scientific community.