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FGF5.

Evelyn A Carrion1, Malcolm M Moses1, Richard R Behringer1

  • 1Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States.

Differentiation; Research in Biological Diversity
|November 13, 2023
PubMed
Summary
This summary is machine-generated.

Fibroblast Growth Factor 5 (FGF5) regulates the hair cycle, acting as a key signal for hair growth termination. Mutations in FGF5 cause abnormal hair growth, like long eyelashes in humans.

Keywords:
AngoraHair cycleInner earTrichomegaly

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Area of Science:

  • Genetics
  • Developmental Biology
  • Mammalian Hair Follicle Biology

Background:

  • Fibroblast Growth Factor 5 (FGF5) is a critical signaling protein.
  • FGF5 regulates the mammalian hair cycle, specifically the transition from anagen to catagen phases.
  • Its expression is localized to the outer root sheath during late anagen.

Purpose of the Study:

  • To elucidate the role of FGF5 in hair cycle regulation.
  • To investigate the phenotypic consequences of FGF5 mutations.
  • To explore FGF5's function in non-hair related tissues.

Main Methods:

  • Analysis of spontaneous and engineered FGF5 mutations in animal models.
  • Clinical observation of human subjects with inherited FGF5 mutations.
  • Gene knockdown studies in zebrafish embryos.

Main Results:

  • FGF5 mutations in mammals lead to phenotypes characterized by extended hair growth (long hair).
  • Human FGF5 mutations are associated with trichomegaly, a condition of excessively long eyelashes.
  • Knockdown of fgf5 in zebrafish embryos results in significant inner ear developmental alterations.

Conclusions:

  • FGF5 is a crucial negative regulator of the hair cycle, promoting the termination of hair growth.
  • FGF5 mutations have direct implications for hair length phenotypes in both animals and humans.
  • FGF5 plays a conserved role in development, with implications beyond hair follicle biology, affecting inner ear development.