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Updated: Jul 11, 2025
Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue
Published on: February 16, 2024
Simple Design for Membrane-Free Microphysiological Systems to Model the Blood-Tissue Barriers
Ashlyn T Young1, Halston Deal1,2, Gabrielle Rusch1,2
1Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, 911 Oval Dr., Raleigh NC, 27695 (USA).
This study introduces a novel, membrane-free blood-tissue interface chip (BTI Chip) for advanced microphysiological systems. The BTI Chip enables high-throughput drug screening and biological research by mimicking tissue barriers with direct cell-to-cell contact.
Area of Science:
- Biomedical Engineering
- Microfluidics
- Tissue Engineering
Background:
- Microphysiological systems (MPS) are crucial for mimicking tissue function but often face limitations in reproducibility and standardization.
- Existing blood-tissue interface (BTI) models struggle with membrane requirements, homogenous cell use, and 2D limitations, hindering realistic endothelial-epithelial contact and 3D transport.
- Current BTI models are complex to assemble, requiring precise component alignment.
Conclusions:
- The engineered BTI Chip provides a physiologically relevant, membrane-free model for studying blood-tissue interfaces.
- This novel design facilitates high-throughput generation of microphysiological systems.
- The BTI Chip holds significant potential for drug candidate screening and fundamental biological investigations.
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