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Advances in Fibrin-Based Bioprinting for Skin Tissue Regeneration: Exploring Design, and Innovative Approaches.
Nooshin Zandi1,2, Michael Daniele1,2,3, Ashley Brown1,2
1Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.
Biomedical Materials & Devices (New York, N.Y.)
|March 23, 2026
Summary
Fibrin-based bioinks are revolutionizing tissue engineering for skin regeneration. These advanced biomaterials promote healing and offer innovative strategies for regenerative medicine.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Tissue engineering and regenerative medicine aim to create functional tissues and organs.
- Biofabrication is key to developing these tissues for transplantation.
- Fibrin, a biocompatible material from the clotting cascade, is vital for bioinks.
Purpose of the Study:
- To review the role of fibrin-based bioinks in tissue regeneration.
- To focus specifically on applications in skin tissue engineering.
- To highlight fibrin's properties and potential in regenerative therapies.
Main Methods:
- Literature review of fibrin-based bioinks in tissue engineering.
- Analysis of fibrin's properties as a biomaterial.
- Evaluation of fibrin's role in angiogenesis and mechanical compatibility.
Main Results:
- Fibrin is a versatile biomaterial for bioink development.
- Fibrin promotes angiogenesis, crucial for tissue repair.
- Fibrin bioinks are compatible with mechanical design considerations.
Conclusions:
- Fibrin-based bioinks show significant potential for innovating tissue engineering strategies.
- These bioinks advance regenerative therapies, particularly for skin.
- Fibrin heralds a new era in tissue engineering applications.
