Related Experiment Video
Updated: Jun 28, 2025
10:04
A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection
Published on: January 7, 2019
7.0K
Infectious Diseases Impact on Biomedical Devices and Materials.
Matthew M Brigmon1, Robin L Brigmon2
1Department of Infectious Diseases and Pulmonary Critical Care, Long School of Medicine, UT Health San Antonio, San Antonio, USA.
Biomedical Materials & Devices (New York, N.Y.)
|April 16, 2024
Summary
Biomedical device infections are a growing problem due to antibiotic resistance. This study reviews challenges, pathogenesis, and novel nanostructured materials for preventing and treating these infections.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Nanotechnology
Background:
- Infectious diseases and nosocomial infections pose significant challenges in healthcare, particularly concerning biomedical materials and devices.
- Current polymer materials often fail to resist microbial growth, exacerbating issues with biomedical implants.
- Increasing microbial antibiotic resistance complicates the management of infections associated with medical devices.
Purpose of the Study:
- To review the challenges in diagnosing device-related infections and their contribution to antibiotic resistance.
- To conceptualize the pathogenesis of device-related infections, focusing on biofilm formation and host immune responses.
- To explore current and future preventative strategies, treatment options, and the development of antimicrobial nanostructured materials for implantable devices.
Main Methods:
- Literature review of device-related infection pathogenesis, diagnosis, and treatment.
- Conceptualization of biofilm formation and host immune/antimicrobial therapy interactions.
- Analysis of current and developing preventative strategies and novel treatment approaches.
- Review of potential manufacturing methods for nanostructured antimicrobial materials.
Main Results:
- Difficulty in diagnosing device-related infections contributes to increased microbial antibiotic resistance.
- Biofilm formation is a critical factor in device-related infections, involving host immune and antimicrobial therapies.
- Current and emerging strategies aim to prevent infectious diseases associated with biomedical devices.
- Development of nanostructured materials with antimicrobial functionality for implantable devices is a promising area.
Conclusions:
- There is a critical need for improved treatment strategies to combat rising antimicrobial resistance.
- Novel nanostructured materials offer potential for enhanced antimicrobial functionality in implantable devices.
- Integrated approaches combining prevention and novel treatments are essential for improving care with biomedical devices.
Related Concept Videos
01:30Bacterial Signaling
32.1K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
32.1K
01:20Infection
7.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.9K
01:26Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
01:22Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
01:25Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.2K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.2K