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Heterogeneous and Composite Bioinks for 3D-Bioprinting of Complex Tissue
Rahimeh Rasouli1, Crystal Sweeney1, John P Frampton1,2
1School of Biomedical Engineering, Dalhousie University, Halifax, Canada.
Biomedical Materials & Devices (New York, N.Y.)
|March 3, 2025
Summary
This review explores nanomaterial fillers for advanced bioinks used in 3D bioprinting. These fillers enhance tissue engineering constructs, enabling stimuli-responsive properties and non-destructive imaging for regenerative medicine applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Bioink composition is critical for 3D bioprinting of stable tissue models and constructs.
- Micro- and nanofillers are emerging to enhance bioink performance without significantly altering bulk properties.
Purpose of the Study:
- To provide a comprehensive overview of novel nanomaterial fillers for heterogeneous and composite bioinks.
- To discuss criteria for developing advanced bioinks and their applications.
Main Methods:
- Review of current literature on nanomaterial fillers in bioinks.
- Analysis of criteria for bioink development.
- Discussion of stimuli-responsive applications and imaging techniques.
Main Results:
- Nanofillers can create advanced bioinks with improved mechanical and functional properties.
- Fillers enable stimuli-responsive behavior (magnetic, electric fields, light) for controlled applications.
- Non-destructive imaging is facilitated for monitoring implanted scaffolds.
Conclusions:
- Nanomaterial fillers are crucial for developing next-generation bioinks for complex tissue engineering.
- Stimuli-responsive and imaging capabilities enhance the utility of 3D-bioprinted constructs in regenerative medicine.
