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Published on: November 21, 2023
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Pulmonary Ventilation Analysis Using 1H Ultra-Short Echo Time (UTE) Lung MRI: A Reproducibility Study
Fei Tan1, Xucheng Zhu2, Marilynn Chan3
1UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, CA.
Biorxiv : the Preprint Server for Biology
|November 14, 2023
Summary
Cyclic registration methods offer superior pulmonary ventilation quantification using ultrashort echo time (UTE) MRI. Specific ventilation demonstrates higher reproducibility in healthy volunteers.
Area of Science:
- Medical Imaging
- Pulmonary Medicine
- Biophysics
Background:
- Accurate quantification of pulmonary ventilation is crucial for diagnosing and monitoring lung diseases.
- Ultrashort echo time (UTE) MRI offers potential for improved lung imaging due to reduced susceptibility artifacts and faster acquisition.
- Assessing ventilation using UTE MRI requires robust image registration and quantification methods.
Conclusions:
- Cyclic registration methods outperform SyN for respiratory phase-resolved 1H UTE MRI ventilation quantification.
- Regional ventilation, calculated using Jacobian determinants, shows better correlation with segmentation lung volume.
- Specific ventilation, derived from intensity differences, is found to be more reproducible.
