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Penile necrosis due to monkeypox.
María Carolina Moreno-Matson1, María A Ocampo1,2, Dayana Sáenz Rengifo3
1School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Urology Case Reports
|November 15, 2023
Summary
Monkeypox virus (MPXV) infection can cause severe penile necrosis, especially in individuals with newly diagnosed HIV and low CD4+ counts. Early recognition and differential diagnosis are crucial for managing this severe MPXV presentation.
Area of Science:
- Infectious Diseases
- Virology
- Dermatology
Background:
- The incidence of Monkeypox virus (MPXV) infections has notably increased since 2022.
- Genitourinary lesions and penile edema are significant reasons for emergency department consultations.
Observation:
- A case study of a 36-year-old male with MPXV infection is presented.
- The patient had a recent diagnosis of Human Immunodeficiency Virus (HIV) and a low CD4+ T-cell count.
- He experienced rapid and extensive penile necrosis.
Findings:
- Surgical debridement was necessitated due to the extensive necrosis.
- Histopathological examination confirmed the necrotic compromise of the penile tissue.
- This case highlights novel presentations of MPXV.
Implications:
- Improved data collection on MPXV presentations is needed.
- Awareness among healthcare workers for accurate differential diagnosis of severe MPXV is critical.
- This case underscores the importance of considering MPXV in patients presenting with severe genital symptoms, particularly those with compromised immune status.

