Systemic Metabolic Signatures of Oral Diseases
A Salminen1, A M Määttä1, P Mäntylä2,3
1Oral and Maxillofacial diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Journal of Dental Research
|November 16, 2023
Summary
Oral diseases like periodontitis are linked to altered blood metabolites, suggesting a connection to systemic inflammation and cardiometabolic disorders. Addressing oral health may help manage these chronic conditions.
Area of Science:
- Biochemistry
- Oral Medicine
- Metabolomics
Background:
- Systemic metabolic impacts of oral diseases are understudied.
- Prospective data on oral health and systemic metabolites are lacking.
Purpose of the Study:
- To investigate associations between current/past oral infectious/inflammatory diseases and circulating metabolites.
- To explore the predictive value of oral health on future metabolic profiles.
Main Methods:
- Utilized data from Health-2000 (n=6,229) and Parogene (n=452) cohorts.
- Measured 157 serum metabolites using nuclear magnetic resonance spectroscopy.
- Employed linear regression models adjusted for confounders.
Main Results:
- Caries associated with altered low-density lipoprotein and fatty acid profiles.
- Periodontal disease linked to dyslipidemia, amino acid changes, and inflammation markers.
- Oral diseases correlated with metabolic signatures indicative of systemic inflammation.
Conclusions:
- Oral infectious/inflammatory conditions are associated with distinct systemic metabolic profiles.
- Periodontitis, in particular, shows strong links to inflammation-related metabolites.
- Oral health may be a modifiable risk factor for chronic systemic inflammation and cardiometabolic diseases.
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