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Introduction to Fibroblasts

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

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Related Experiment Video

Updated: Jul 11, 2025

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Ultrasonic-augmented Primary Adult Fibroblast Isolation

Published on: July 29, 2019

COX Postulates: Remember the Fibroblast

Garret A FitzGerald¹

¹Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA.

Arteriosclerosis, Thrombosis, and Vascular Biology

|November 16, 2023

Summary

No abstract available in PubMed .

Keywords:

Editorials aspirin cell membrane prostaglandin rofecoxib

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