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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
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Localized Delivery of Bioactives using Structured Liposomal Gels
Deepak Kumar1, Kamal Dua2, Sanjay Tiwari1
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) - Raebareli, Lucknow 226002, India.
Current Pharmaceutical Design
|November 17, 2023
Summary
Hydrogels stabilize liposomes, preventing premature drug leakage and improving dispersion. This approach enhances localized drug delivery, particularly for skin applications, minimizing systemic exposure.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutics
Background:
- Liposomes are widely used for drug delivery due to biocompatible components and versatile payload capacity.
- Key limitations include poor dispersion stability and premature payload leakage.
- Commercialized liposome preparations highlight their therapeutic potential.
Approach:
- This review discusses stabilizing liposomes by entrapping them within hydrogel matrices.
- Hydrogels maintain liposome structural integrity and modulate release kinetics.
- Release control is achieved by selecting appropriate matrix formers and cross-linking densities.
Key Points:
- Hydrogel entrapment significantly enhances liposome stability and prevents premature drug release.
- The release rate of liposomes from hydrogels can be precisely controlled.
- This strategy is particularly effective for localized drug delivery applications.
Conclusions:
- Liposome-entombed hydrogels offer a promising strategy for advanced drug delivery systems.
- This approach is ideal for localized delivery, such as topical or transdermal applications.
- It effectively minimizes systemic distribution and off-target effects of therapeutic payloads.
