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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Tissue Transplantation01:24

Tissue Transplantation

375
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Updated: Jul 11, 2025

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Liver Transplantation: Contraindication and Ineligibility.

Pankaj Puri1, Sarthak Malik2

  • 1Fortis Escorts Liver and Digestive Diseases Institute, Fortis Escorts Hospital, New Delhi 110025, India.

Journal of Clinical and Experimental Hepatology
|November 17, 2023
PubMed
Summary

Liver transplantation (LT) is a critical treatment for advanced liver disease, but careful patient selection is vital. This review examines contraindications and ineligibility criteria for LT to ensure optimal outcomes.

Keywords:
acute liver failurechronic liver diseasecontraindicationsineligibilityliver transplantation

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Area of Science:

  • Hepatology
  • Transplant Surgery
  • Medical Ethics

Background:

  • Liver transplantation (LT) is a life-saving procedure for end-stage liver disease.
  • Accurate patient assessment is crucial to determine transplant eligibility and optimize outcomes.
  • Identifying contraindications prevents futile procedures and improves resource allocation.

Purpose of the Study:

  • To review the critical considerations for determining patient eligibility for liver transplantation.
  • To explore contraindications and factors influencing the decision of when not to transplant.
  • To emphasize the importance of appropriate timing for liver transplantation.

Main Methods:

  • Literature review of contraindications and ineligibility for liver transplantation.
  • Analysis of factors influencing transplant candidacy, including comorbidities and disease severity.
  • Discussion of special considerations for specific patient groups (elderly, ACLD, HCC).

Main Results:

  • Careful patient selection is paramount to avoid unacceptable outcomes post-LT.
  • Specific patient groups (elderly, ACLD, comorbidities, HCC) require meticulous evaluation.
  • Appropriate timing of LT is essential to prevent unnecessary procedures or missed opportunities.

Conclusions:

  • Timely and appropriate selection of liver transplant candidates is critical.
  • Understanding contraindications and ineligibility is key to successful LT programs.
  • This review provides a framework for decision-making in complex LT cases.