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FAPI Uptake in Gallbladder Is It Normal Biodistribution?
Hossein Behnam-Manesh1, Abtin Doroudinia2, Mohadeseh Bayat1
1From the Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical Nuclear Medicine
|November 17, 2023
Summary
Radiolabeled fibroblast activation protein inhibitors (FAPIs) show accumulation in the gallbladder, a potential normal biodistribution finding. This observation is significant for the future theranostic applications of FAPIs in various diseases.
Area of Science:
- Nuclear medicine
- Oncology
- Radiochemistry
Background:
- Radiolabeled fibroblast activation protein inhibitors (FAPIs) are utilized in oncology for cancer imaging.
- FAPI expression is observed in nonmalignant conditions involving tissue remodeling, such as atherosclerosis, arthritis, and fibrosis.
- The normal biodistribution patterns of FAPIs are crucial for accurate interpretation of imaging studies.
Purpose of the Study:
- To report the observation of 68Ga-FAPI accumulation in the gallbladder.
- To discuss the potential implications of this finding for FAPI biodistribution and theranostic applications.
Main Methods:
- Utilized Gallium-68 (68Ga) labeled FAPIs for imaging.
- Observed and analyzed the biodistribution pattern of the radiotracer.
Main Results:
- Demonstrated the accumulation of 68Ga-FAPI in the gallbladder.
- This accumulation is hypothesized to represent a normal physiological finding.
Conclusions:
- Gallbladder uptake of 68Ga-FAPI may be a normal biodistribution pattern.
- This finding has implications for the interpretation of FAPI-based imaging and its future theranostic potential.
![An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F66708.jpg&w=3840&q=50)
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