Jove
Visualize
Contact Us

Related Concept Videos

Gallbladder01:17

Gallbladder

564
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
564
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

2.7K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
2.7K
Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

239
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
239
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

6.4K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
6.4K
Bioavailability: Overview01:13

Bioavailability: Overview

2.8K
Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting multi-nodal radiomics with advanced feature learning for lymphoma classification: a multi-center study.

Physics in medicine and biology·2026
Same author

Prostate Anatomy: What Is Relevant for a Nuclear Medicine Practitioner.

Journal of nuclear medicine technology·2026
Same author

Prognostic Value of <sup>18</sup>F-FDG and <sup>18</sup>F-FEC Uptake in Hepatocellular Carcinoma Using Contrast-Enhanced Integrated PET/MRI: Correlation with Histology and Survival.

Cancers·2026
Same author

Impact of partial volume correction on radiomics reproducibility in theranostic SPECT/CT imaging.

Medical physics·2026
Same author

Evaluating the impact of partial volume correction on FDG PET radiomics stability in lymphoma lesions.

Physical and engineering sciences in medicine·2026
Same author

Quantitative Amyloid Brain Imaging: A Literature Review of the Centiloid Scale in Alzheimer Disease Evaluation.

Journal of nuclear medicine technology·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 11, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

11.2K

FAPI Uptake in Gallbladder Is It Normal Biodistribution?

Hossein Behnam-Manesh1, Abtin Doroudinia2, Mohadeseh Bayat1

  • 1From the Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinical Nuclear Medicine
|November 17, 2023
PubMed
Summary

Radiolabeled fibroblast activation protein inhibitors (FAPIs) show accumulation in the gallbladder, a potential normal biodistribution finding. This observation is significant for the future theranostic applications of FAPIs in various diseases.

More Related Videos

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
10:33

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use

Published on: May 24, 2024

808
Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

13.4K

Related Experiment Videos

Last Updated: Jul 11, 2025

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

11.2K
An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
10:33

An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use

Published on: May 24, 2024

808
Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

13.4K

Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiochemistry

Background:

  • Radiolabeled fibroblast activation protein inhibitors (FAPIs) are utilized in oncology for cancer imaging.
  • FAPI expression is observed in nonmalignant conditions involving tissue remodeling, such as atherosclerosis, arthritis, and fibrosis.
  • The normal biodistribution patterns of FAPIs are crucial for accurate interpretation of imaging studies.

Purpose of the Study:

  • To report the observation of 68Ga-FAPI accumulation in the gallbladder.
  • To discuss the potential implications of this finding for FAPI biodistribution and theranostic applications.

Main Methods:

  • Utilized Gallium-68 (68Ga) labeled FAPIs for imaging.
  • Observed and analyzed the biodistribution pattern of the radiotracer.

Main Results:

  • Demonstrated the accumulation of 68Ga-FAPI in the gallbladder.
  • This accumulation is hypothesized to represent a normal physiological finding.

Conclusions:

  • Gallbladder uptake of 68Ga-FAPI may be a normal biodistribution pattern.
  • This finding has implications for the interpretation of FAPI-based imaging and its future theranostic potential.