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Related Experiment Video

Updated: Jul 10, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Sex differences in patients with primary hyperparathyroidism.

Katherine A Baugh1, Jason B Liu2, Linwah Yip1

  • 1Department of Surgery, University of Pittsburgh, Pittsburgh, PA.

Surgery
|November 18, 2023
PubMed
Summary
This summary is machine-generated.

Women experience significant symptom improvement after parathyroidectomy, as measured by the Pasieka Parathyroidectomy Assessment Score. Men show less apparent symptom changes, possibly due to outcome tool limitations.

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Area of Science:

  • Endocrinology
  • Surgical Outcomes

Background:

  • Primary hyperparathyroidism symptom presentation and parathyroidectomy outcomes differ between sexes.
  • The utility of the Pasieka Parathyroidectomy Assessment Score (PPAS) in evaluating these sex-based differences is unknown.

Approach:

  • A prospective database of 701 primary hyperparathyroidism patients (Jan 2016-Dec 2019) was reviewed.
  • Patients completed the PPAS, assessing 13 symptoms via visual analog scale (0-1,300), preoperatively and postoperatively.
  • Only patients with 6-month cure after initial parathyroidectomy were included.

Key Points:

  • The cohort was 77% female. Women had higher median preoperative PPAS (155) than men (80.5, P < .001).
  • Post-parathyroidectomy, women showed a 35% reduction in symptomatology at the initial visit and 48% by 6 months (P < .001).
  • Men experienced smaller, though statistically significant, PPAS reductions (initial visit P=.036, 6-month P=.048).

Conclusions:

  • The Pasieka Parathyroidectomy Assessment Score effectively demonstrates significant symptom improvement in women following curative parathyroidectomy.
  • Symptom improvement in men is less evident, potentially indicating limitations in current outcome assessment tools for evaluating sex-based disparities.